(42378:21*27:54*40-82*6+45615)*7=
(42378 : 21 * 27 : 54 * 40 - 82 * 6 + 45615) * 7 = (2018 * 27 : 54 * 40 - 492 + 45615) * 7 = (54486 : 54 * 40 - 492 + 45615) * 7 = (1009 * 40 - 492 + 45615) * 7 = (40360 - 492 + 45615) * 7 = 85483 * 7 = 598381. Ответ: 598381.