1. Is there a large building in that square?
Is there a large building in that square or in this one?
There is a large building in that square, isn't it?
Where is a large building?
2. Are there any methods of research in their lab?
Are there any methods of research or analyzes in their lab?
There are various methods of research in their lab, are there?
What do they have in their lab?
3. Are there four dining-rooms in the main building of the University?
Are there four or five dining-rooms in the main building of the University?
There are four dining-rooms in the main building of the University, are there?
How did it happen, that there are four dining-rooms in the main building of the University?
4. Are some parents angry with their children?
Are some parents angry or pleased with their children?
Some parents are always angry with their children, are they?
Who is always angry with their children?
5. Is his friend a smart software engineer?
Is his friend a smart software engineer or a smart doctor?
His friend is a smart software engineer, isn't he?
Who is his friend?