While Grew illustration in " Despicable Me 2" , ex- supervillain adapts to family life and trying to lead an honest business , the secret laboratory Arctic stolen. League Antizlodeya decides that needs help and insider takes Grew on research . Together with the eccentric agent AVL, Lucy Wylde , Gru finds that his main suspect - alleged dead supervillain , El Macho , whose teenage son is interested in his eldest daughter , Margot . Apparently blinded the safety of his children and his growing mutual attraction with Lucy , Grew is on the wrong track , just as his favorites quietly stolen from some malevolent purpose